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KMID : 0043320080310111381
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Archives of Pharmacal Research
2008 Volume.31 No. 11 p.1381 ~ p.1384
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A New Abietane Diterpenoid from Isodon inflexus
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Hwang Bang-Yeon
Lee Mi-Kyeong
Li Dayu
Han Xiang-Hua
Hong Seong-Soo
Lee Chul
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Abstract
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A new ent-abietane diterpenoid, 3α,6β-dihydroxy-7,17-dioxo-ent-abieta-15(16)-ene (1), and three known ent-kaurane diterpenids, kamebacetal A (2), kamebakaurin (3), and excisanin A (4), and a known triterpenoid, ursolic acid (5), were isolated from the aerial parts of Isodon inflexus. Their chemical structures were determined by extensive analysis of spectroscopic data including 1D- and 2D-NMR experiments. All isolates (1-5) were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 1-4 inhibited the production of NO with IC50 values ranging from 1.0 to 26.5 μM.
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KEYWORD
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Isodon inflexus, Lamiaceae, ent-Abietane, Nitric oxide production inhibitor
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